PT-141 (Bremelanotide)
Bremelanotide, FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. Use by men is off-label.
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This substance is approved by regulators as a medicine and is dispensed on prescription. The dose is chosen by a doctor. The calculator below converts a dose you have already been prescribed into syringe units — it does not replace a prescription.
Bremelanotide is FDA-approved (Vyleesi) only for hypoactive sexual desire disorder in premenopausal women. The male use described below is off-label.
Every figure on this page is a dose reported in published sources. It is reference information, not a recommendation and not a protocol to follow. Any decision about injecting is one to make with a doctor.
Medical disclaimerWhat is PT-141?
Bremelanotide, a melanocortin receptor agonist. Unlike the PDE-5 inhibitors it does not act on blood vessels but on the central nervous system — on desire rather than on blood flow.
It is one of the few peptides in this catalogue that is a registered medicine. The FDA approved it on 21 June 2019 under the name Vyleesi, for acquired generalised hypoactive sexual desire disorder in premenopausal women and nothing else.
Use by men is not approved and is off-label. Phase 2 studies in men were run: in a group of 21 men, 80% reported a satisfying sexual experience, 52% an improvement in erectile function and 39% an increase in desire, with onset in 30 to 60 minutes.
What follows is dosing arithmetic and numeric protocols drawn from published sources and clinical trials. It describes what those sources report; it is not medical advice and not instructions for use. This part of the page is meant for people aged 18 and over.
The confirmation is kept in this browser, and on the account for signed-in users. The peptide description and its regulatory status are available without it.
What follows is dosing arithmetic and numeric protocols drawn from published sources and clinical trials. It describes what those sources report; it is not medical advice and not instructions for use. This part of the page is meant for people aged 18 and over.
The confirmation is kept in this browser, and on the account for signed-in users. The peptide description and its regulatory status are available without it.
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